| Year | Winner | Party | Votes | Vote % | Runner-up | Party | Margin |
|---|---|---|---|---|---|---|---|
| 2026 | Dr. T. K. Prabhu | TVK | 101358 | 44.21% | S. Mangudi | INC | 46074 |
| 2021 | S. Mangudi | INC | 75954 | 35.75% | H. Raja | BJP | 21589 |
| 2016 | Ramasamy Kr | INC | 93419 | 46.40% | Karpagam Ilango | ADMK | 18283 |
| 2011 | Palanichamy Cholan Ct | AIADMK | 86104 | 51.01% | Ramasamy Kr | INC | 18900 |
| 2006 | Durai Chandrasekaran | DMK | 52723 | 46.01% | Durai Govindarajan | ADMK | 366 |
| 2001 | K. Ayyaru Vandayar | AIADMK | 55579 | 54.75% | Durai Chandrasekaran | DMK | 15689 |
| 1996 | D. Chandrasekaran | DMK | 57429 | 56.32% | M. Subramanian | ADMK | 27011 |
| 1991 | P. Kalaiperumal | ADMK | 57648 | 59.68% | Durai Chandrasekaran | DMK | 20399 |
| 1989 | Durai Chandraseharan | DMK | 36981 | 38.28% | V. C. Ganesan Alias Svajiganesan | IND | 10643 |
| 1984 | Durai Govindarajan | AIADMK | 46974 | 55.75% | Ramamurthy A. | TNC(K) | 13089 |
| 1980 | Subramanian. M. | AIADMK | 42636 | 55.14% | Elangovan. G. | DMK | 9669 |
| 1977 | G. Elangovan | DMK | 28500 | 36.96% | P. C. Palaniyandi | AIADMK | 5303 |
| 1971 | Manali Kandasami C. | CPI | 40714 | 62.84% | Thayamanavang G. | INC | 18596 |
| 1967 | N. Dharumalingam | DMK | 23728 | 38.04% | K. C. Manali | CPI | 1502 |
| 1962 | N. V. Venugopalakrishnasami | INC | 22158 | 36.22% | R. S. Appasami | SWA | 4099 |
Practising doctor from Sivaganga district — medical professional background.
Joined TVK at formation on 2 February 2024.
Key TVK organiser for Sivaganga–Karaikudi region.
Won Karaikudi with 1,01,358 votes — margin of 46,074. Strong mandate from Chettinad heartland.
Sworn in as Phase 1 Minister for Minerals, Mines and Natural Resources.